Dendritic cells (DCs) play a central role in the immune defense. They take up foreign antigens, process and present them to the T cells for a specific immune response. In order to be able to properly perform this function, DCs undergo a well-programmed process called maturation. Nowadays, the concept of maturation is becoming the centre of attention since it has been suggested that inhibition of maturation could be the reason for evasion of some infectious agents as well as tumor cells from the immune system. However, all aspects of this process are not well known, and mature DCs are being generated by using different methods to be used as vaccine carriers for infectious diseases or cancer immunotherapy. Here we present this biological process in order to have a mathematical model designed for the level of maturity as an approach to simplify and standardize this process for better comparison between laboratories and interpretation or prediction of results in experiments and trials.